(A and B) Western blots detecting SPL expression in homogenates of SPLF and SPLTECKO mouse thymuses (A) and spleens (B). mature T cells through positive and negative selection. The population of mature T cells egressing from the thymus exhibits a diverse repertoire of antigen recognition capable of mounting effective protective immunity, yet lacking autoreactivity. Tight … Continue reading (A and B) Western blots detecting SPL expression in homogenates of SPLF and SPLTECKO mouse thymuses (A) and spleens (B)